Protein Information

Name P glycoprotein
Synonyms ABC20; MDR1; ABCB 1; ABCB1; ATP binding cassette sub family B member 1; CD243; CD243 antigen; CLCS…

Compound Information

Name piperonyl butoxide
CAS 5-[[2-(2-butoxyethoxy)ethoxy]methyl]-6-propyl-1,3-benzodioxole

Reference List

PubMed Abstract RScore(About this table)
8898877 Lanning CL, Fine RL, Corcoran JJ, Ayad HM, Rose RL, Abou-Donia MB: Tobacco budworm P-glycoprotein: biochemical characterization and its involvement in pesticide resistance. Biochim Biophys Acta. 1996 Oct 24;1291(2):155-62.

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7906712 Murray CL, Quaglia M, Arnason JT, Morris CE: A putative nicotine pump at the metabolic blood-brain barrier of the tobacco hornworm. J Neurobiol. 1994 Jan;25(1):23-34.


In mammals, P-glycoprotein immunostaining at the blood-brain barrier has implicated the multidrug pump in the restricted movement of many cytotoxic agents into the central nervous system (CNS).
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9473291 Mustacich DJ, Shields J, Horton RA, Brown MK, Reed DJ: Biliary secretion of alpha-tocopherol and the role of the mdr2 P-glycoprotein in rats and mice. Arch Biochem Biophys. 1998 Feb 15;350(2):183-92.

The mechanism by which alpha-tocopherol (alpha-T) is secreted into the bile is not known; however, we have previously demonstrated that treatment with piperonyl butoxide (PIP, 1 g/kg) results in increased biliary output of both alpha-T and phosphatidylcholine within 3 h of ip injection in rats and that the biliary output of both substances was prevented by chemicals that disrupt microtubules (Toxicol.
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