| Name | demethylase |
|---|---|
| Synonyms | DMTase; Demethylase; MBD 2; MBD2; Methyl CpG binding domain protein 2; Methyl CpG binding protein MBD2; NY CO 41; Demethylases… |
| Name | piperonyl butoxide |
|---|---|
| CAS | 5-[[2-(2-butoxyethoxy)ethoxy]methyl]-6-propyl-1,3-benzodioxole |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 1889377 | Dalvi RR, Dalvi PS: Differences in the effects of piperine and piperonyl butoxide on hepatic drug-metabolizing enzyme system in rats. Drug Chem Toxicol. 1991;14(1-2):219-29. An i.p. administration of rats with piperine (100 mg/kg) and piperonyl butoxide (400 mg/kg) produced a significant decrease in hepatic cytochrome P-450, and activities of benzphetamine N-demethylase, aminopyrine N-demethylase and hydroxylase 1 hr after the treatment. |
6(0,0,1,1) | Details |
| 3977942 | Dahl AR, Brezinski DA: Inhibition of rabbit nasal and hepatic cytochrome P-450-dependent hexamethylphosphoramide (HMPA) N-demethylase by methylenedioxyphenyl compounds. Biochem Pharmacol. 1985 Mar 1;34(5):631-6. |
3(0,0,0,3) | Details |
| 1269658 | Friedman MA, Sanders V: Acute toxicity of dimethylnitrosamine in the presence of inhibitors of DMN demethylase. Experientia. 1976 Apr 15;32(4):495-6. Piperonyl butoxide, dibutylnitrosamine and nitrososarcosine had no effect on the acute toxicity of DMN. |
2(0,0,0,2) | Details |
| 6814016 | Fisher CW, Mayer RT: Characterization of house fly microsomal mixed function oxidases: inhibition by juvenile hormone i and piperonyl butoxide. Toxicology. 1982;24(1):15-31. The inhibition of these reactions by juvenile hormone I (E, E cis methyl 10,11-epoxy-7-ethyl-3, 11-dimethyl-2, 6-tridecadienoate, JH-I) was competitive for the N-demethylase, epoxidase and the formation of the PB metabolite-complex. |
2(0,0,0,2) | Details |
| 1933335 | Pai KS, Ravindranath V: Protection and potentiation of MPTP-induced toxicity by cytochrome P-450 inhibitors and inducer: in vitro studies with brain slices. Brain Res. 1991 Aug 2;555(2):239-44. However, both pargyline and deprenyl also inhibited cytochrome P-450 mediated aminopyrine N-demethylase activity in brain slices. Other cytochrome P-450 inhibitors, namely, piperonyl butoxide and SKF 525A were found to offer protection against MPTP induced neurotoxicity in slices without affecting monoamine oxidase activity. |
1(0,0,0,1) | Details |
| 11455659 | Yun MS, Shim IS, Usui K: Involvement of cytochrome P-450 enzyme activity in the selectivity and safening action of pyrazosulfuron-ethyl. Pest Manag Sci. 2001 Mar;57(3):283-8. To investigate the selectivity and safening action of the sulfonylurea herbicide pyrazosulfuron-ethyl (PSE), pyrazosulfuron-ethyl O-demethylase (PSEOD) activity involving oxidative metabolism by cytochrome P-450 was studied in rice (Oryza sativa L cv Nipponbare) and Cyperus serotinus Rottb. |
1(0,0,0,1) | Details |
| 994247 | Friedman MA, Sanders V: Effects of piperonyl butoxide on dimethylnitrosamine metabolism and toxicity in Swiss mice. J Toxicol Environ Health. 1976 Sep;2(1):67-75. PB, at doses of 10 and 20 mg/kg, inhibited DMN demethylase 45 min after treatment by 18 and 37%. |
1(0,0,0,1) | Details |
| 2541521 | Moorthy B, Madyastha P, Madyastha KM: Hepatotoxicity of pulegone in rats: its effects on microsomal enzymes, in vivo. Toxicology. 1989 May 15;55(3):327-37. A significant decrease in aminopyrine N-demethylase was also noticed after pulegone administration. Pretreatment of rats with phenobarbital (PB) or diethylmaleate (DEM) potentiated the hepatotoxicity caused by pulegone, whereas, pretreatment with 3-methylcholanthrene (3-MC) or piperonyl butoxide protected from it. |
1(0,0,0,1) | Details |
| 10985040 | Valles SM, Oi FM, Wagner T, Brenner RJ: Toxicity and in vitro metabolism of t-permethrin in eastern subterranean termite (Isoptera: Rhinotermitidae). J Econ Entomol. 2000 Aug;93(4):1259-64. The synergists piperonyl butoxide and S,S,S-tributylphosphorotrithioate increased t-permethrin toxicity four- and threefold (at the LC50) in the UF and ARS colonies, respectively. |
0(0,0,0,0) | Details |
| 19533589 | Wang D, Qiu X, Ren X, Zhang W, Wang K: Effects of spinosad on Helicoverpa armigera (Lepidoptera: Noctuidae) from China: tolerance status, synergism and enzymatic responses. Pest Manag Sci. 2009 Sep;65(9):1040-6. The toxicity of spinosad could be synergised by piperonyl butoxide (PBO) and triphenylphosphate (TPP), but not by diethyl maleate (DEM). |
0(0,0,0,0) | Details |
| 7062265 | Kuo CH, Rush GF, Hook JB: Renal cortical accumulation of phenobarbital in rats and rabbits: lack of correlation with induction of renal microsomal monooxygenases. J Pharmacol Exp Ther. 1982 Mar;220(3):547-51. Renal cortical accumulation of phenobarbital in rats was also inhibited by piperonyl butoxide. |
0(0,0,0,0) | Details |
| 7196448 | Hyslop RM, Jardine I: Metabolism of 6-thiopurines. J Pharmacol Exp Ther. 1981 Sep;218(3):629-35. Binding to hepatic microsomal protein was decreased by pretreatment with phenobarbital or piperonyl butoxide, but not significantly with allopurinol. 6-Thiopurine at therapeutic doses had no apparent negative effects on either hepatocellular levels or hepatic microsomal aminopyrine N-demethylase activity during this time period. |
0(0,0,0,0) | Details |
| 7184943 | Kluwe WM, Herrmann-Kluwe CL, Hook JB: Inhibition of mixed-function oxidase activities in vitro and in vivo: comparisons between kidney and liver. J Appl Toxicol. 1982 Oct;2(5):226-30. The concentration-dependent abilities of SKF 525-A, (MET), piperonyl butoxide (PB), allyl-isopropylacetamide (AIA) and alpha-naphthoflavone (7,8-benzoflavone; ANF) to inhibit the activities of p-chloro-N-methylaniline-N-demethylase (PCNMA) and aryl hydrocarbon hydroxylase (AHH) in vitro were determined in microsomal and postmitochondrial supernatant (PMS) fractions of homogenates prepared from kidneys and livers of rats and mice. |
81(1,1,1,1) | Details |
| 2803241 | Ravindranath V, Ananda Theertha Varada HK: High activity of cytochrome P-450-linked aminopyrine N-demethylase in mouse brain microsomes, and associated sex-related difference. Biochem J. 1989 Aug 1;261(3):769-73. Aminopyrine N-demethylase activity in mouse brain microsomes was dependent on the presence of and and could be inhibited by piperonyl butoxide, N-octyl and |
35(0,1,1,5) | Details |
| 3941395 | Fouin-Fortunet H, Tinel M, Descatoire V, Letteron P, Larrey D, Geneve J, Pessayre D: Inactivation of cytochrome P-450 by the drug methoxsalen. . J Pharmacol Exp Ther. 1986 Jan;236(1):237-47. In vitro, the concentration of methoxsalen inhibiting by 50% monooxygenase activities ranged from 10 microM (for benzo (a)-pyrene and hexobarbital hydroxylases] to 25 microM for 7-ethoxy- deethylase and aminopyrine demethylase); these values were in the range of those observed with SKF 525-A (1-50 microM) or piperonyl butoxide (10-100 microM) but much lower than those for cimetidine (100-500 microM). |
31(0,1,1,1) | Details |
| 12192904 | Durham EW, Siegfried BD, Scharf ME: In vivo and in vitro metabolism of fipronil by larvae of the European corn borer Ostrinia nubilalis. Pest Manag Sci. 2002 Aug;58(8):799-804. Cytochrome P450-dependent monooxygenase activity (methoxyresorufin O-demethylase) was consistently observed in midgut preparations, and formation and detection of the sulfone metabolite in the same midgut preparations was also -dependent and inhibited by piperonyl butoxide. |
31(0,1,1,1) | Details |
| 4667438 | Bick M, Fishbein L: The inductive effect of piperonyl butoxide on microsomal demethylase activity. Sci Total Environ. 1972 Aug;1(2):197-203. |
6(0,0,1,1) | Details |
| 7389009 | Fennell TR, Sweatman BC, Bridges JW: The induction of hepatic cytochrome P-450 in C57 BL/10 and DBA/2 mice by isosafrole and piperonyl butoxide. Chem Biol Interact. 1980 Aug;31(2):189-201. The capacity of isosafrole and piperonyl butoxide to induced cytochrome P-450 was evaluated by measurement of biphenyl 2- and 4-hydroxylase, ethoxyresofurin O-deethylase and ethylmorphine N-demethylase and by (SDS) polyacrylamide gel electrophoresis and compared with results obtained for phenobarbitone, 3-methylcholanthrene and -16 alpha-carbonitrile. |
6(0,0,1,1) | Details |