| Name | microsomal monooxygenases |
|---|---|
| Synonyms | CPC 8; Flavoprotein linked monooxygenase; Xenobiotic monooxygenase; CPC8; CYP2C8; CYPIIC 8; CYPIIC8; Cytochrome P 450 1… |
| Name | piperonyl butoxide |
|---|---|
| CAS | 5-[[2-(2-butoxyethoxy)ethoxy]methyl]-6-propyl-1,3-benzodioxole |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 3358959 | Nedel'kina SV, Solomennikova IV, Lukashina NS, Leonova IN, Raushenbakh IIu: [Enzymatic systems of insecticide detoxication in a population of Colorado beetles resistant to permethrin]. Biokhimiia. 1988 Jan;53(1):11-7. It was demonstrated that the inhibitors of microsomal monooxygenases, piperonyl butoxide, and of nonspecific esterases, butifos, significantly increase the sensitivity of the resistant population to permetrin. |
33(0,1,1,3) | Details |
| 17598550 | Sims SR, Appel AG: Linear ethoxylates: insecticidal and synergistic effects on German cockroaches (Blattodea: Blattellidae) and other insects. J Econ Entomol. 2007 Jun;100(3):871-9. The insecticidal activity of Tomadol 23-1 was synergized by coapplication with a sublethal amount of piperonyl butoxide, indicating the involvement of cytochrome P450 microsomal monooxygenases in insect metabolism of AEO surfactants. |
31(0,1,1,1) | Details |
| 2891472 | Gordon WP, Huitric AC, Seth CL, McClanahan RH, Nelson SD: The metabolism of the abortifacient terpene, (R)-(+)-pulegone, to a proximate toxin, menthofuran. Drug Metab Dispos. 1987 Sep-Oct;15(5):589-94. (R)-(+)-Pulegone, the major monoterpene component of the abortifacient mint oil, pennyroyal oil, is metabolized by hepatic microsomal monooxygenases of the mouse to a hepatotoxin. Furthermore, two inhibitors of cytochromes P-450, cobaltous and piperonyl butoxide, block toxicity. |
1(0,0,0,1) | Details |
| 12192904 | Durham EW, Siegfried BD, Scharf ME: In vivo and in vitro metabolism of fipronil by larvae of the European corn borer Ostrinia nubilalis. Pest Manag Sci. 2002 Aug;58(8):799-804. Cytochrome P450-dependent monooxygenase activity (methoxyresorufin O-demethylase) was consistently observed in midgut preparations, and formation and detection of the sulfone metabolite in the same midgut preparations was also -dependent and inhibited by piperonyl butoxide. In vitro metabolism results indicate microsomal monooxygenases are responsible for the conversion of fipronil to its sulfone form in the European corn borer. |
1(0,0,0,1) | Details |
| 7062265 | Kuo CH, Rush GF, Hook JB: Renal cortical accumulation of phenobarbital in rats and rabbits: lack of correlation with induction of renal microsomal monooxygenases. J Pharmacol Exp Ther. 1982 Mar;220(3):547-51. Renal cortical accumulation of phenobarbital in rats was also inhibited by piperonyl butoxide. |
1(0,0,0,1) | Details |