| Name | cytochrome b5 |
|---|---|
| Synonyms | CYB 5; CYB5; CYB5A; Cytochrome b 5; Cytochrome b5; MCB 5; MCB5; Microsomal cytochrome b5… |
| Name | piperonyl butoxide |
|---|---|
| CAS | 5-[[2-(2-butoxyethoxy)ethoxy]methyl]-6-propyl-1,3-benzodioxole |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 3083808 | Scott JG, Georghiou GP: The biochemical genetics of permethrin resistance in the Learn-PyR strain of house fly. Biochem Genet. 1986 Feb;24(1-2):25-37. Three factors were associated with resistance: (1) increased mixed-function oxidase (MFO) activity associated with elevated levels of cytochrome P-450, cytochrome b5, and -cytochrome c reductase (P-450 reductase) activity; (2) target-site insensitivity (kdr); and (3) decreased cuticular penetration. Permethrin resistance factors on chromosome 1 consisted of a piperonyl butoxide (PB)-suppressible mechanism correlated with increased levels of cytochromes P-450 and b5; on chromosome 2, a PB-suppressible mechanism associated with elevated amounts of cytochrome P-450; on chromosome 3, decreased cuticular penetration, kdr, and increased amounts of P-450 reductase activity; and on chromosome 5, a largely PB-suppressible mechanism correlated with elevated levels of cytochrome P-450 and P-450 reductase activity. |
1(0,0,0,1) | Details |
| 1889377 | Dalvi RR, Dalvi PS: Differences in the effects of piperine and piperonyl butoxide on hepatic drug-metabolizing enzyme system in rats. Drug Chem Toxicol. 1991;14(1-2):219-29. Twenty-four hr later, these parameters along with cytochrome b5 and -cytochrome c reductase remained depressed only in piperine-treated rats. |
1(0,0,0,1) | Details |
| 6198504 | Yamamoto T, Egashira T, Yamanaka Y, Yoshida T, Kuroiwa Y: Initial metabolism of gamma-hexachlorocyclohexane (gamma-HCH) by rat liver microsomes. J Pharmacobiodyn. 1983 Oct;6(10):721-8. Thus, the results suggest that the dehydrochlorination could be catalyzed by a specific species of cytochrome P-450 and cytochrome b5 system and/or other microsomal enzyme systems. The dehydrogenation was inhibited by SKF 525-A, CO, piperonyl butoxide, N2 and the absence of but not by |
1(0,0,0,1) | Details |
| 2541521 | Moorthy B, Madyastha P, Madyastha KM: Hepatotoxicity of pulegone in rats: its effects on microsomal enzymes, in vivo. Toxicology. 1989 May 15;55(3):327-37. Pretreatment of rats with phenobarbital (PB) or diethylmaleate (DEM) potentiated the hepatotoxicity caused by pulegone, whereas, pretreatment with 3-methylcholanthrene (3-MC) or piperonyl butoxide protected from it. |
0(0,0,0,0) | Details |