| PubMed |
Abstract |
RScore(About this table) |
| 19172188 |
Colombo G, Meli M, Morra G, Gabizon R, Gasset M: Methionine sulfoxides on prion protein Helix-3 switch on the alpha-fold destabilization required for conversion. PLoS One. 2009;4(1):e4296. Epub 2009 Jan 27.
METHODOLOGY/PRINCIPAL FINDINGS: Using molecular dynamics simulation, essential dynamics, correlated motions and signal propagation analysis, we have found that substitution of the sulfur atom of M213 by a sulfoxide group impacts on the stability of the native state increasing the flexibility of regions preceding the site of the modification and perturbing the network of stabilizing interactions. |
2(0,0,0,2) |
Details |
| 20020713 |
Grabenauer M, Wu C, Soto P, Shea JE, Bowers MT: Oligomers of the prion protein fragment 106-126 are likely assembled from beta-hairpins in solution, and methionine oxidation inhibits assembly without altering the peptide's monomeric conformation. J Am Chem Soc. 2010 Jan 20;132(2):532-9.
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2(0,0,0,2) |
Details |
| 20121218 |
Silva CJ, Onisko BC, Dynin I, Erickson ML, Vensel WH, Requena JR, Antaki EM, Carter JM: Assessing the role of oxidized methionine at position 213 in the formation of prions in hamsters. Biochemistry. 2010 Mar 9;49(9):1854-61.
Prions are infectious proteins that are able to recruit a normal cellular prion protein and convert it into a prion. |
3(0,0,0,3) |
Details |