Protein Information

Name PCNA
Synonyms Cyclin; DNA polymerase delta auxillary protein; PCNA; Proliferating cell nuclear antigen; DNA polymerase delta auxillary proteins; Proliferating cell nuclear antigens

Compound Information

Name sulfoxide
CAS 5-[2-(octylsulfinyl)propyl]-1,3-benzodioxole

Reference List

PubMed Abstract RScore(About this table)
18665442 Ling HY, Hu B, Wang BX, Zu XY, Feng SD, Ou HS, Zhou SH, Liao DF: Effects of rosiglitazone on the proliferation of vascular smooth muscle cell induced by high glucose. Cardiovasc Drugs Ther. 2008 Dec;22(6):453-60. Epub 2008 Jul 31.


The protein expressions of proliferating cell nuclear antigen (PCNA) and matrix metalloproteinases-2 (MMP-2) were evaluated by Western blotting.
4(0,0,0,4) Details
19358267 Onori P, DeMorrow S, Gaudio E, Franchitto A, Mancinelli R, Venter J, Kopriva S, Ueno Y, Alvaro D, Savage J, Alpini G, Francis H: Caffeic acid phenethyl ester decreases cholangiocarcinoma growth by inhibition of NF-kappaB and induction of apoptosis. Int J Cancer. 2009 Aug 1;125(3):565-76.


Cell cycle decrease was seen by a decrease in PCNA protein expression and the number of BrdU-positive cells treated with CAPE at 20 microM compared to vehicle.
1(0,0,0,1) Details
19785986 Zhuo L, Gong J, Yang R, Sheng Y, Zhou L, Kong X, Cao K: Inhibition of proliferation and differentiation and promotion of apoptosis by cyclin L2 in mouse embryonic carcinoma P19 cells. Biochem Biophys Res Commun. 2009 Dec 18;390(3):451-7. Epub 2009 Sep 26.


Cyclin L2 (CCNL2) is a novel member of the cyclin gene family.
1(0,0,0,1) Details
18381210 Cuello C, Sanchez-Osorio J, Alminana C, Gil MA, Perals ML, Lucas X, Roca J, Vazquez JM, Martinez EA: Effect of the cryoprotectant concentration on the in vitro embryo development and cell proliferation of OPS-vitrified porcine blastocysts. Cryobiology. 2008 Jun;56(3):189-94. Epub 2008 Feb 29.


Some vitrified and fresh embryos were processed for Hoechst 33342 staining and proliferation cell nuclear antigen (PCNA) inmunolocalization to determine the proliferation index.
1(0,0,0,1) Details
18584482 Lee SC, Chan WK, Lee TW, Lam WH, Wang X, Chan TH, Wong YC: Effect of a prodrug of the green tea polyphenol (-)-epigallocatechin-3-gallate on the growth of androgen-independent prostate cancer in vivo. Nutr Cancer. 2008;60(4):483-91.


The effects of both EGCG and EGCG-P on tumor cell proliferation were assessed by immunohistochemical (IHC) method using antibodies against Ki-67 and proliferating cell nuclear antigen.
1(0,0,0,1) Details
18725974 She QB, Chandarlapaty S, Ye Q, Lobo J, Haskell KM, Leander KR, DeFeo-Jones D, Huber HE, Rosen N: Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling. PLoS One. 2008 Aug 26;3(8):e3065.


In sensitive cells, pathway inhibition resulted in D-cyclin loss, G1 arrest and induction of apoptosis, whereas cells without pathway activation were unaffected.
1(0,0,0,1) Details
18954600 Flanigan TL, Owen CR, Gayer C, Basson MD: Supraphysiologic extracellular pressure inhibits intestinal epithelial wound healing independently of luminal nutrient flow. Am J Surg. 2008 Nov;196(5):683-9.


We induced mucosal ulcers by serosal acetic acid, and assessed proliferation (proliferating cell nuclear antigen) and ERK (immunoblotting).
1(0,0,0,1) Details
18725217 Aerts JM, De Clercq JB, Andries S, Leroy JL, Van Aelst S, Bols PE: Follicle survival and growth to antral stages in short-term murine ovarian cortical transplants after Cryologic solid surface vitrification or slow-rate freezing. Cryobiology. 2008 Oct;57(2):163-9. Epub 2008 Aug 7.


In grafted tissue, follicular survival and growth was assessed by conventional histological examination and proliferating cell nuclear antigen immunohistochemistry.
1(0,0,0,1) Details
17427960 Chen H, Yang S, Yang Z, Ma L, Jiang D, Mao J, Jiao B, Cai Z: Inhibition of GSK-3beta decreases NF-kappaB-dependent gene expression and impairs the rat liver regeneration. J Cell Biochem. 2007 Dec 1;102(5):1281-9.


Moreover, the injection of SB216763 impaired the proliferation cell nuclear antigen (PCNA) index and increased the apoptosis of liver compared to the vehicle.
1(0,0,0,1) Details
17451196 Baek JY, Hur W, Wang JS, Bae SH, Yoon SK: Selective COX-2 inhibitor, NS-398, suppresses cellular proliferation in human hepatocellular carcinoma cell lines via cell cycle arrest. World J Gastroenterol. 2007 Feb 28;13(8):1175-81.


Proliferating cell nuclear antigen (PCNA) expressions in HepG2 and Huh7 cells, particularly in Huh7 cells were inhibited in a time- and dose-independent manner.
1(0,0,0,1) Details