Protein Information

Name alpha synuclein
Synonyms Alpha synuclein; PARK4; PD1; NACP; Non A beta component of AD amyloid; Non A4 component of amyloid; Non A4 component of amyloid precursor; PARK 1…

Compound Information

Name sulfoxide
CAS 5-[2-(octylsulfinyl)propyl]-1,3-benzodioxole

Reference List

PubMed Abstract RScore(About this table)
19653131 Oien DB, Shinogle HE, Moore DS, Moskovitz J: Clearance and phosphorylation of alpha-synuclein are inhibited in methionine sulfoxide reductase a null yeast cells. J Mol Neurosci. 2009 Nov;39(3):323-32. Epub 2009 Aug 4.

6(0,0,0,6) Details
17504092 Kim S, Kang M, Ryu Y, Kim TD: A short C-terminal region of alpha-synuclein protects a (R/S)-non-specific esterase from Archaeglobus fulgidus. Protein Pept Lett. 2007;14(4):347-51.

3(0,0,0,3) Details
18239841 Kowalik-Jankowska T, Rajewska A, Jankowska E, Grzonka Z: Products of Cu (II)-catalyzed oxidation of alpha-synuclein fragments containing M1-D2 and H50 residues in the presence of hydrogen peroxide. Dalton Trans. 2008 Feb 14;(6):832-8. Epub 2007 Dec 4.

2(0,0,0,2) Details
18032652 Wassef R, Haenold R, Hansel A, Brot N, Heinemann SH, Hoshi T: Methionine sulfoxide reductase A and a dietary supplement S-methyl-L-cysteine prevent Parkinson's-like symptoms. J Neurosci. 2007 Nov 21;27(47):12808-16.


Here, we show that one member of the MSR family, MSRA, inhibits development of the locomotor and circadian rhythm defects caused by ectopic expression of human alpha-synuclein in the Drosophila nervous system.
2(0,0,0,2) Details
20064662 Lucas HR, Lee JC: Effect of dioxygen on copper (II) binding to alpha-synuclein. . J Inorg Biochem. 2010 Mar;104(3):245-9. Epub 2009 Dec 23.

2(0,0,0,2) Details
18456002 Liu F, Hindupur J, Nguyen JL, Ruf KJ, Zhu J, Schieler JL, Bonham CC, Wood KV, Davisson VJ, Rochet JC: Methionine sulfoxide reductase A protects dopaminergic cells from Parkinson's disease-related insults. Free Radic Biol Med. 2008 Aug 1;45(3):242-55. Epub 2008 Apr 11.


PD pathogenesis involves mitochondrial dysfunction, proteasome impairment, and alpha-synuclein aggregation, insults that may be especially toxic to oxidatively stressed cells including dopaminergic neurons.
2(0,0,0,2) Details