| Name | CYP3A |
|---|---|
| Synonyms | CP33; CYP3; HLP; CYP3A; CP34; CYP 3A4; CYP 3; CYP3A3… |
| Name | sulfoxide |
|---|---|
| CAS | 5-[2-(octylsulfinyl)propyl]-1,3-benzodioxole |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19022943 | Bakken GV, Rudberg I, Christensen H, Molden E, Refsum H, Hermann M: Metabolism of by CYP3A4 and CYP3A5 in presence or absence of cytochrome B5. Drug Metab Dispos. 2009 Feb;37(2):254-8. Epub 2008 Nov 20. Formation of the metabolites sulfoxide, N-desalkylquetiapine, O-desalkylquetiapine, and 7-hydroxyquetiapine by CYP3A4 and CYP3A5 were compared in the different microsomal preparations. |
40(0,1,1,10) | Details |
| 19451401 | Li AP: Evaluation of luciferin-isopropyl acetal as a CYP3A4 substrate for human hepatocytes: effects of organic solvents, cytochrome P450 (P450) inhibitors, and P450 inducers. Drug Metab Dispos. 2009 Aug;37(8):1598-603. Epub 2009 May 18. |
6(0,0,0,6) | Details |
| 19905875 | Nishiya Y, Nakamura K, Okudaira N, Abe K, Kobayashi N, Okazaki O: Effects of organic solvents on the time-dependent inhibition of CYP3A4 by diazepam. Xenobiotica. 2010 Jan;40(1):1-8. |
4(0,0,0,4) | Details |
| 17883958 | Fan L, Wang G, Wang LS, Chen Y, Zhang W, Huang YF, Huang RX, Hu DL, Wang D, Zhou HH: Herbal medicine yin zhi huang induces CYP3A4-mediated sulfoxidation and CYP2C19-dependent hydroxylation of Acta Pharmacol Sin. 2007 Oct;28(10):1685-92. |
3(0,0,0,3) | Details |
| 17344101 | Mortensen AS, Arukwe A: Modulation of xenobiotic biotransformation system and hormonal responses in Atlantic salmon (Salmo salar) after exposure to tributyltin (TBT). Comp Biochem Physiol C Toxicol Pharmacol. 2007 Apr;145(3):431-41. Epub 2007 Feb 2. The AhRbeta, CYP3A and diphosphoglucuronosyl transferase (UGT) mRNA expressions were significantly induced after exposure to TBT. |
3(0,0,0,3) | Details |
| 18385292 | Kanebratt KP, Andersson TB: Evaluation of HepaRG cells as an in vitro model for human drug metabolism studies. Drug Metab Dispos. 2008 Jul;36(7):1444-52. Epub 2008 Apr 2. Compared with human hepatocytes, expression of P450 in HepaRG cells was in general lower with the exception for a considerably higher expression of CYP3A4 and CYP7A1. |
3(0,0,0,3) | Details |
| 17344341 | Kammerer B, Scheible H, Albrecht W, Gleiter CH, Laufer S: Pharmacokinetics of ML3403 ({4-[5-(4-fluorophenyl)-2-methylsulfanyl-3H--4-yl]-pyridin-2-yl}-( 1-phenylethyl)-amine), a 4-Pyridinylimidazole-type p38 mitogen-activated protein kinase inhibitor. Drug Metab Dispos. 2007 Jun;35(6):875-83. Epub 2007 Mar 7. In addition, pharmacokinetics of ML3403 were evaluated in male and female Wistar rats after oral gavage, showing a fast and high conversion to its active sulfoxide metabolite ML3603. Incubations were carried out with hepatic microsomes from various species and with recombinant human cytochrome P450 isoenzymes, showing that CYP1A2, CYP2C19, CYP2D6, and CYP3A4 are the prominent enzymes in the metabolism of ML3403. |
2(0,0,0,2) | Details |
| 20019244 | Antherieu S, Chesne C, Li R, Camus S, Lahoz A, Picazo L, Turpeinen M, Tolonen A, Uusitalo J, Guguen-Guillouzo C, Guillouzo A: Stable expression, activity, and inducibility of cytochromes P450 in differentiated HepaRG cells. Drug Metab Dispos. 2010 Mar;38(3):516-25. Epub 2009 Dec 17. Thus, CYP1A2, CYP2B6, and CYP3A4 were found to accurately respond to their respective prototypical inducers, i.e., phenobarbital, and rifampicin. |
1(0,0,0,1) | Details |
| 19775530 | Miyamoto Y, Ikeya T, Enosawa S: Preconditioned cell array optimized for a three-dimensional culture of hepatocytes. Cell Transplant. 2009;18(5):677-81. The CYP3A drug metabolism activities of the hepatocytes were well maintained on the cryopreserved and fresh cell arrays. |
1(0,0,0,1) | Details |
| 18617602 | Grondin M, Hamel F, Sarhan F, Averill-Bates DA: Metabolic activity of cytochrome p450 isoforms in hepatocytes cryopreserved with wheat protein extract. Drug Metab Dispos. 2008 Oct;36(10):2121-9. Epub 2008 Jul 10. This was achieved by comparing basal and inducible or metabolic activities of isoforms CYP1A1, CYP1A2, CYP2C6, CYP2D2, and CYP3A in rat hepatocytes that were cryopreserved with WPE, relative to fresh cells and those cryopreserved with DMSO. |
1(0,0,0,1) | Details |
| 19562329 | Corti N, Heck A, Rentsch K, Zingg W, Jetter A, Stieger B, Pauli-Magnus C: Effect of ritonavir on the pharmacokinetics of the benzimidazoles albendazole and mebendazole: an interaction study in healthy volunteers. Eur J Clin Pharmacol. 2009 Oct;65(10):999-1006. Epub 2009 Jun 27. The aim of the present study was to investigate potential drug interactions between the benzimidazoles albendazole and mebendazole and the potent CYP3A4 inhibitor ritonavir. AUC, C (max), and t (1/2) of mebendazole, albendazole, and albendazole sulfoxide were studied in absence and after short-term (2 doses) and long-term (8 days) treatment with ritonavir 200 mg bid. |
1(0,0,0,1) | Details |
| 19231942 | Turner BA, Evans BP, Pearson TT, Braden TK, Wise SC: Examination of edge effects with different storage conditions of preplated nanospots in ChemLib 1,536- and 3,456-well assay-ready plates. Assay Drug Dev Technol. 2008 Dec;6(6):811-8. Using a cytochrome P450 3A4 Vivid Blue assay (Invitrogen, Carlsbad), we investigated the rate, pattern, and quantity of evaporation over a 1-year time frame to identify best practices for long-term (i.e., 6 months or greater) storage of assay-ready compound plates. |
1(0,0,0,1) | Details |