Protein Information

Name methionine sulfoxide reductase B
Synonyms CBS 1; CBS1; CGI 131; MSRB; MSRB 2; MSRB2; Methionine sulfoxide reductase B2; Methionine R sulfoxide reductase B…

Compound Information

Name sulfoxide
CAS 5-[2-(octylsulfinyl)propyl]-1,3-benzodioxole

Reference List

PubMed Abstract RScore(About this table)
19542914 Taungjaruwinai WM, Bhawan J, Keady M, Thiele JJ: Differential expression of the antioxidant repair enzyme methionine sulfoxide reductase (MSRA and MSRB) in human skin. Am J Dermatopathol. 2009 Jul;31(5):427-31.

Recently, the antioxidant repair enzymes methionine-S-sulfoxide reductase A (MSRA) and methionine-R-sulfoxide reductase B (MSRB) were described in human epidermal keratinocytes and melanocytes.
9(0,0,1,4) Details
20026324 Pascual I, Larrayoz IM, Campos MM, Rodriguez IR: Methionine sulfoxide reductase B2 is highly expressed in the retina and protects retinal pigmented epithelium cells from oxidative damage. Exp Eye Res. 2010 Mar;90(3):420-8. Epub 2009 Dec 22.

6(0,0,0,6) Details
18424444 Cabreiro F, Picot CR, Perichon M, Castel J, Friguet B, Petropoulos I: Overexpression of mitochondrial methionine sulfoxide reductase B2 protects leukemia cells from oxidative stress-induced cell death and protein damage. J Biol Chem. 2008 Jun 13;283(24):16673-81. Epub 2008 Apr 17.

6(0,0,0,6) Details
20236937 Tarrago L, Laugier E, Zaffagnini M, Marchand CH, Le Marechal P, Lemaire SD, Rey P: The plant thioredoxin CDSP32 regenerates 1-CYS methionine sulfoxide reductase B activity through the direct reduction of sulfenic acid. J Biol Chem. 2010 Mar 17.

4(0,0,0,4) Details
17761174 Vieira Dos Santos C, Laugier E, Tarrago L, Massot V, Issakidis-Bourguet E, Rouhier N, Rey P: Specificity of thioredoxins and glutaredoxins as electron donors to two distinct classes of Arabidopsis plastidial methionine sulfoxide reductases B. FEBS Lett. 2007 Sep 18;581(23):4371-6. Epub 2007 Aug 14.


Using recombinant proteins, we show that Arabidopsis plastidial MSRB1 and MSRB2, which differ regarding the number of presumed redox-active cysteines, possess specific reductants.
3(0,0,0,3) Details
19457862 Tarrago L, Laugier E, Zaffagnini M, Marchand C, Le Marechal P, Rouhier N, Lemaire SD, Rey P: Regeneration mechanisms of Arabidopsis thaliana methionine sulfoxide reductases B by glutaredoxins and thioredoxins. J Biol Chem. 2009 Jul 10;284(28):18963-71. Epub 2009 May 20.


In the present work we used recombinant plastidial Arabidopsis thaliana MSRB1 and MSRB2 as models for 1-Cys and 2-Cys MSRBs, respectively, to delineate the Trx- and glutaredoxin-dependent reduction mechanisms.
3(0,0,0,3) Details
20006300 Dhandayuthapani S, Jagannath C, Nino C, Saikolappan S, Sasindran SJ: Methionine sulfoxide reductase B (MsrB) of Mycobacterium smegmatis plays a limited role in resisting oxidative stress. Tuberculosis. 2009 Dec;89 Suppl 1:S26-32.

2(0,0,0,2) Details
19874542 Laugier E, Tarrago L, Dos Santos CV, Eymery F, Havaux M, Rey P: Arabidopsis thaliana plastidial methionine sulfoxide reductases B, MSRBs, account for most leaf peptide MSR activity and are essential for growth under environmental constraints through a role in the preservation of photosystem antennae. Plant J. 2010 Jan;61(2):271-82. Epub 2009 Oct 26.


Two MSRB isoforms, MSRB1 and MSRB2, are present in chloroplasts of Arabidopsis thaliana.
3(0,0,0,3) Details
19415325 Guo X, Wu Y, Wang Y, Chen Y, Chu C: OsMSRA4.1 and OsMSRB1.1, two rice plastidial methionine sulfoxide reductases, are involved in abiotic stress responses. Planta. 2009 Jun;230(1):227-38. Epub 2009 May 5.


In proteins, methionine residues are especially sensitive to oxidation, leading to the formation of S- and R-methionine sulfoxide diastereoisomers, and these two methionine sulfoxides can be specifically reversed by two types of methionine sulfoxide reductases (MSRs), MSRA and MSRB.
2(0,0,0,2) Details
17766244 Neiers F, Sonkaria S, Olry A, Boschi-Muller S, Branlant G: Characterization of the amino acids from Neisseria meningitidis methionine sulfoxide reductase B involved in the chemical catalysis and substrate specificity of the reductase step. J Biol Chem. 2007 Nov 2;282(44):32397-405. Epub 2007 Aug 31.

The Msr family is composed of two structurally unrelated classes of enzymes named MsrA and MsrB, which display opposite stereoselectivities toward the S and R isomers of the sulfoxide function, respectively.
1(0,0,0,1) Details
20167203 Uthus EO: Determination of the specific activities of methionine sulfoxide reductase A and B by capillary electrophoresis. Anal Biochem. 2010 Feb 16.

A capillary electrophoresis (CE) method for the determination of methionine sulfoxide reductase A and methionine sulfoxide reductase B activities in mouse liver is described.
The method is based on detection of the 4-(dimethylamino) azobenzene-4'-sulfonyl derivative of l-methionine (dabsyl Met), the product of the enzymatic reactions when either dabsyl l-methionine S-sulfoxide or dabsyl l-methionine R-sulfoxide is used as a substrate.
1(0,0,0,1) Details
17943184 Schallreuter KU, Rubsam K, Gibbons NC, Maitland DJ, Chavan B, Zothner C, Rokos H, Wood JM: Methionine sulfoxide reductases A and B are deactivated by hydrogen peroxide (H2O2) in the epidermis of patients with vitiligo. J Invest Dermatol. 2008 Apr;128(4):808-15. Epub 2007 Oct 18.

Such high concentrations of H (2) O (2) oxidize L-methionine residues in proteins and peptides to (R and S)-methionine sulfoxide diasteriomers.
In this report, we show that the expression/activities of MSRA and MSRB are significantly decreased in the epidermis of patients with vitiligo compared to healthy controls.
1(0,0,0,1) Details
19733575 Ranaivoson FM, Neiers F, Kauffmann B, Boschi-Muller S, Branlant G, Favier F: Methionine sulfoxide reductase B displays a high level of flexibility. J Mol Biol. 2009 Nov 20;394(1):83-93. Epub 2009 Sep 4.

MsrB are stereospecific to R epimer on the sulfur of sulfoxide.
1(0,0,0,1) Details
18239417 Park AK, Shin YJ, Moon JH, Kim YK, Hwang KY, Chi YM: Overexpression, purification, and preliminary X-ray crystallographic studies of methionine sulfoxide reductase B from Bacillus subtilis. J Microbiol Biotechnol. 2008 Jan;18(1):59-62.

1(0,0,0,1) Details
19636904 Breivik AS, Aachmann FL, Sal LS, Kim HY, Del Conte R, Gladyshev VN, Dikiy A: 1H, 15N and 13C NMR assignments of mouse methionine sulfoxide reductase B2. Biomol NMR Assign. 2008 Dec;2(2):199-201. Epub 2008 Oct 4.

1(0,0,0,1) Details