Protein Information

Name c jun
Synonyms AP1; Activator protein 1; JUN; Proto oncogene c jun; Protooncogene c jun; Transcription factor AP 1; V jun avian sarcoma virus 17 oncogene homolog; c Jun…

Compound Information

Name sulfoxide
CAS 5-[2-(octylsulfinyl)propyl]-1,3-benzodioxole

Reference List

PubMed Abstract RScore(About this table)
17403295 Chen XL, Xia ZF, Wei D, Ben DF, Tang HT, Ge SD: [Role of c-Jun NH (2)-terminal kinase in insulin resistance after burn] . Zhonghua Wai Ke Za Zhi. 2007 Jan 1;45(1):62-4.

2(0,0,0,2) Details
17395177 Kishioka T, Iida C, Fujii K, Nagae R, Onishi Y, Ichi I, Kojo S: Effect of dimethyl sulphoxide on oxidative stress, activation of mitogen activated protein kinase and necrosis caused by thioacetamide in the rat liver. Eur J Pharmacol. 2007 Jun 14;564(1-3):190-5. Epub 2007 Mar 12.


Phosphorylated c-Jun NH (2)-terminal kinase (JNK) significantly increased transiently 12 h after treatment with thioacetamide.
1(0,0,0,1) Details
19436652 Vikman P, Xu CB, Edvinsson L: Lipid-soluble cigarette smoking particles induce expression of inflammatory and extracellular-matrix-related genes in rat cerebral arteries. Vasc Health Risk Manag. 2009;5(1):333-41. Epub 2009 Apr 8.


In addition, the activity of three mitogen-activated protein kinases (p38, ERK 1/2 and SAPK/JNK) and their downstream transcription factors (ATF-2, Elk-1 and c-Jun) were examined.
1(0,0,0,1) Details
19690165 Catalgol B, Ziaja I, Breusing N, Jung T, Hohn A, Alpertunga B, Schroeder P, Chondrogianni N, Gonos ES, Petropoulos I, Friguet B, Klotz LO, Krutmann J, Grune T: The proteasome is an integral part of solar ultraviolet a radiation-induced gene expression. J Biol Chem. 2009 Oct 30;284(44):30076-86. Epub 2009 Aug 18.


This proteasomal inhibition subsequently led to an accumulation of c-Jun and phosphorylated c-Jun and activation of activator protein-1, i.e. transcription factors known to control MMP-1 expression.
1(0,0,0,1) Details
19782097 Datta S, Mazumder S, Ghosh D, Dey S, Bhattacharya S: Low concentration of arsenic could induce caspase-3 mediated head kidney macrophage apoptosis with JNK-p38 activation in Clarias batrachus. Toxicol Appl Pharmacol. 2009 Dec 15;241(3):329-38. Epub 2009 Sep 24.


Exposure of HKM to arsenic induced the activation of mitogen-activated protein kinase family (MAPK) proteins including c-Jun NH (2)-terminal protein kinase (JNK) and p38 mitogen-activated protein kinase (p38).
1(0,0,0,1) Details