Protein Information

Name Myosin
Synonyms Myosin

Compound Information

Name sulfoxide
CAS 5-[2-(octylsulfinyl)propyl]-1,3-benzodioxole

Reference List

PubMed Abstract RScore(About this table)
17549043 Shiga KI, Hirano K, Nishimura J, Niiro N, Naito S, Kanaide H: Dimethyl sulphoxide relaxes rabbit detrusor muscle by decreasing the Ca2+ sensitivity of the contractile apparatus. Br J Pharmacol. 2007 Aug;151(7):1014-24. Epub 2007 Jun 4.


EXPERIMENTAL APPROACH: The effects of DMSO on contraction, on Ca2+ sensitivity of myofilaments, and on myosin light chain (MLC) phosphorylation were investigated in both intact and alpha-toxin-permeabilized strips of rabbit detrusor muscle.
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18001554 Xue HJ, Li WM, Li Y, Gong YT, Sheng L, Zhang L, Chu S: [Effect of calpain 1 on structural remodeling and contractile dysfunction in atrial fibrillation: experiment with dogs]. Zhonghua Yi Xue Za Zhi. 2007 Aug 28;87(32):2285-8.


Western blotting was used to detect the protein expression of troponin I (TnI) and myosin.
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17520663 Wen J, Xia Q, Lu C, Yin L, Hu J, Gong Y, Yin B, Monzen K, Yuan J, Qiang B, Zhang X, Peng X: Proteomic analysis of cardiomyocytes differentiation in mouse embryonic carcinoma P19CL6 cells. J Cell Biochem. 2007 Sep 1;102(1):149-60.


We demonstrated that P19CL6 cells indeed differentiated into cardiomyocytes after DMSO inducement as they expressed sarcomeric myosin heavy chain (MHC) as well as three cardiac-specific transcription factors (Csx/Nkx-2.5, GATA-4, and MEF2C).
1(0,0,0,1) Details
19949579 Yang J, Ko SJ, Kim BS, Kim HS, Park S, Hong D, Hong SW, Choi JH, Park CY, Choi SC, Hong SJ, Lim DS: Enhanced cardiomyogenic differentiation of p19 embryonal carcinoma stem cells. Korean Circ J. 2009 May;39(5):198-204. Epub 2009 May 28.


RESULTS: Quantitative real-time polymerase chain reaction (PCR) analysis showed that the messenger ribonucleic acid (mRNA) expression of cardiac muscle-specific genes, such as GATA4, alpha-actin, alpha-myosin heavy chain, and cardiac troponin T, were significantly higher in the 15-day culture groups than in the 10-day culture groups.
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18990676 van Hees HW, Dekhuijzen PN, Heunks LM: Levosimendan enhances force generation of diaphragm muscle from patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2009 Jan 1;179(1):41-7. Epub 2008 Oct 31.


Results were grouped per myosin heavy chain isoform, which was determined by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE).
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19011258 Gillardin V, Silvestre F, Dieu M, Delaive E, Raes M, Thome JP, Kestemont P: Protein expression profiling in the African clawed frog Xenopus laevis tadpoles exposed to the polychlorinated biphenyl mixture aroclor 1254. Mol Cell Proteomics. 2009 Apr;8(4):596-611. Epub 2008 Nov 16.


They also affect, at least at the highest concentration tested, the synthesis of proteins involved in normal cytogenesis (alpha-tropomyosin, myosin heavy chain, and alpha-actin).
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20063901 Fedorova M, Kuleva N, Hoffmann R: Identification of cysteine, methionine and tryptophan residues of actin oxidized in vivo during oxidative stress. J Proteome Res. 2010 Mar 5;9(3):1598-609.

Relative to the control, the actin functions studied in vitro were reduced for (i) actin polymerization to a minimum of 33% after 9 h and (ii) actin activated Mg (2+)-ATPase activity of myosin to 55% after 9 h.
The content of methionine sulfoxides also increased for 15 of the 16 methionine residues, with Met (44), Met (47), and Met (355) having the highest sulfoxide contents.
1(0,0,0,1) Details