Protein Information

Name ATPase
Synonyms ATP7A; MK; ATPase; Cation transporting ATPase; ATP7A protein; ATPase Cu(2+) transporting alpha polypeptide; Copper pump 1; Copper transporting ATPase 1…

Compound Information

Name sulfoxide
CAS 5-[2-(octylsulfinyl)propyl]-1,3-benzodioxole

Reference List

PubMed Abstract RScore(About this table)
17960046 Pan QH, Zhang YJ, Liu YY, Zhang YF, Huang WD: [Changes in H2O2 and salicylic acid contents as well as plasma membrane H+-ATPase activity and their relations in pea leaves during thermotolerance induction]. Zhi Wu Sheng Li Yu Fen Zi Sheng Wu Xue Xue Bao. 2007 Oct;33(5):425-34.

6(0,0,0,6) Details
17652835 Ramesh B, Pugalendi KV: Influence of umbelliferone on membrane-bound ATPases in streptozotocin-induced diabetic rats. Pharmacol Rep. 2007 May-Jun;59(3):339-48.


In our study, diabetic rats had increased level of blood glucose and lipid peroxidation markers, and decreased level of plasma insulin and decreased activities of total ATPases, (Na (+)+K (+))-ATPase, low affinity Ca (2+)-ATPase and Mg (2+)-ATPase in erythrocytes and tissues.
1(0,0,0,1) Details
17623887 Sangeetha T, Darlin Quine S: Preventive effect of S-allyl cysteine sulfoxide (alliin) on lysosomal hydrolases and membrane-bound ATPases in isoproterenol-induced myocardial infarction in Wistar rats. J Biochem Mol Toxicol. 2007;21(3):118-24.

The activity of Na (+) K (+)-ATPase declined, while those of Ca (2+)- and Mg (2+)-ATPases significantly (p < 0.05) elevated in the heart of ISO-induced rats.
1(0,0,0,1) Details
18591782 Yang L, Jiang C, Liu F, You QD, Wu WT: Cloning, enzyme characterization of recombinant human Eg5 and the development of a new inhibitor. Biol Pharm Bull. 2008 Jul;31(7):1397-402.


The effects of temperature, pH, metal ions and DMSO on ATPase activity were investigated.
1(0,0,0,1) Details
18515580 Koyama Y, Matsuzaki S, Gomi F, Yamada K, Katayama T, Sato K, Kumada T, Fukuda A, Matsuda S, Tano Y, Tohyama M: Induction of amyloid beta accumulation by ER calcium disruption and resultant upregulation of angiogenic factors in ARPE19 cells. Invest Ophthalmol Vis Sci. 2008 Jun;49(6):2376-83.


METHODS: The authors used two endoplasmic reticulum (ER) stress-inducing reagents, thapsigargin (TG), which inhibits the sarcoplasmic/endoplasmic calcium (Ca) 2+-ATPase, and tunicamycin (TM), which inhibits N-linked glycosylation.
1(0,0,0,1) Details
18582096 Duarte AM, van Mierlo CP, Hemminga MA: Molecular dynamics study of the solvation of an alpha-helical transmembrane peptide by DMSO. J Phys Chem B. 2008 Jul 24;112(29):8664-71. Epub 2008 Jun 27.


The 25-residue peptide (sMTM7) used mimics the cytoplasmic proton hemichannel domain of the seventh transmembrane segment (TM7) from subunit a of H (+)-V-ATPase from Saccharomyces cerevisiae.
1(0,0,0,1) Details
20063901 Fedorova M, Kuleva N, Hoffmann R: Identification of cysteine, methionine and tryptophan residues of actin oxidized in vivo during oxidative stress. J Proteome Res. 2010 Mar 5;9(3):1598-609.

Relative to the control, the actin functions studied in vitro were reduced for (i) actin polymerization to a minimum of 33% after 9 h and (ii) actin activated Mg (2+)-ATPase activity of myosin to 55% after 9 h.
The content of methionine sulfoxides also increased for 15 of the 16 methionine residues, with Met (44), Met (47), and Met (355) having the highest sulfoxide contents.
1(0,0,0,1) Details
18539598 Mahmmoud YA: Capsaicin stimulates uncoupled ATP hydrolysis by the sarcoplasmic reticulum calcium pump. J Biol Chem. 2008 Aug 1;283(31):21418-26. Epub 2008 Jun 6.


In muscle cells the sarcoplasmic reticulum (SR) Ca (2+)-ATPase (SERCA) couples the free energy of ATP hydrolysis to pump Ca (2+) ions from the cytoplasm to the SR lumen.
1(0,0,0,1) Details
17957304 Yang N, Tanner JA, Wang Z, Huang JD, Zheng BJ, Zhu N, Sun H: Inhibition of SARS coronavirus helicase by bismuth complexes. . Chem Commun. 2007 Nov 14;(42):4413-5. Epub 2007 Aug 16.


A series of bismuth complexes were synthesized and characterized, and most of them exhibited inhibition against the SARS coronavirus helicase ATPase and duplex-unwinding activities at micromolar concentrations.
1(0,0,0,1) Details
19323274 Vasic D, Savic J, Bugarcic Z, Krstic D, Tomic N, Colovic M, Petkovic M, Vasic V: Interaction of the [PtCl2 (DMSO) 2] complex with L-cysteine. . Z Naturforsch C. 2009 Jan-Feb;64(1-2):103-8.


Additionally, the inhibitory effect of [PtCl2 (DMSO) 2] on the Na+,K+-ATPase activity and its partial prevention with 10 mM L-Cys were demonstrated.
1(0,0,0,1) Details