Protein Information

Name interleukin 4
Synonyms B cell differentiation factor gamma; B cell growth factor; B cell stimulatory factor 1; BCDF gamma; BCDFg; BCDFgamma; BCGF; BSF 1…

Compound Information

Name sulfoxide
CAS 5-[2-(octylsulfinyl)propyl]-1,3-benzodioxole

Reference List

PubMed Abstract RScore(About this table)
18256785 Yu HN, Lee YR, Noh EM, Lee KS, Song EK, Han MK, Lee YC, Yim CY, Park J, Kim BS, Lee SH, Lee SJ, Kim JS: Tumor necrosis factor-alpha enhances DMSO-induced differentiation of HL-60 cells through the activation of ERK/MAPK pathway. Int J Hematol. 2008 Mar;87(2):189-94. Epub 2008 Feb 8.


Higher efficient methods to differentiate promyelocytic leukemic cells have been developed using various differentiation inducers including interferon-alpha, interleukin-4, tumor necrosis factor-alpha (TNF-alpha), and dimethyl sulfoxide (DMSO) as a single agent or in combination with each other.
1(0,0,0,1) Details
18157297 Deolinda de Oliveira Pena J, Melo GB, Gomes JA, Haapalainen EF, Komagome CM, Santos NC, Souza Lima Filho AA, Rizzo LV: [Ultrastructural and growth factor analysis of amniotic membrane preserved by different methods for ocular surgery]. Arq Bras Oftalmol. 2007 Sep-Oct;70(5):756-62.


The cytokines and growth factors assessed were: TGF-beta (transforming growth factor beta); TGF-beta activ (activated transforming growth factor beta); EGF (epidermal growth factor); FGF-4 (fibroblast growth factor 4); bFGF (basic fibroblast growth factor); IL-4 (interleukin 4); PGE2 (prostaglandin E2); IL-10 (interleukin 10); KGF (keratinocyte growth factor); HGF (hepatocyte growth factor).
1(0,0,0,1) Details
18005266 Ratthe C, Girard D: Investigation of the interleukin (IL)-4/IL-4 receptor system in promyelocytic leukaemia PLB-985 cells during differentiation toward neutrophil-like phenotype: mechanism involved in IL-4-induced SOCS3 protein expression. Br J Haematol. 2008 Jan;140(1):59-70. Epub 2007 Nov 12.

7(0,0,0,7) Details
19159656 Wichmann G, Franck U, Herbarth O, Rehwagen M, Dietz A, Massolo L, Ronco A, Muller A: Different immunomodulatory effects associated with sub-micrometer particles in ambient air from rural, urban and industrial areas. Toxicology. 2009 Mar 29;257(3):127-36. Epub 2008 Dec 31.


Vitality/proliferation was quantified using MTT, released interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) by ELISA.
4(0,0,0,4) Details