Protein Information

Name IL 1beta
Synonyms Catabolin; IL 1; IL 1 beta; IL 1B; IL1 beta; IL1B; IL1F2; Interleukin 1…

Compound Information

Name sulfoxide
CAS 5-[2-(octylsulfinyl)propyl]-1,3-benzodioxole

Reference List

PubMed Abstract RScore(About this table)
17382630 Lu K, Cho CL, Liang CL, Chen SD, Liliang PC, Wang SY, Chen HJ: Inhibition of the MEK/ERK pathway reduces microglial activation and interleukin-1-beta expression in spinal cord ischemia/reperfusion injury in rats. J Thorac Cardiovasc Surg. 2007 Apr;133(4):934-41.

4(0,0,0,4) Details
19966493 Saegusa S, Totsuka M, Kaminogawa S, Hosoi T: Saccharomyces cerevisiae and Candida albicans stimulate cytokine secretion from human neutrophil-like HL-60 cells differentiated with retinoic acid or dimethylsulfoxide. Biosci Biotechnol Biochem. 2009 Dec;73(12):2600-8. Epub 2009 Dec 7.


Intact and heat-killed S. cerevisiae enhanced secretion of interleukin (IL)-1beta, IL-6, IL-8, IL-12, IL-18, MCP-1/CCL2 and TNF-alpha from retinoic acid-treated HL-60 cells, accompanied by alterations in mRNA expression of the cytokines.
2(0,0,0,2) Details
17639882 Iseda K, Ono S, Onoda K, Satoh M, Manabe H, Nishiguchi M, Takahashi K, Tokunaga K, Sugiu K, Date I: Antivasospastic and antiinflammatory effects of caspase inhibitor in experimental subarachnoid hemorrhage. J Neurosurg. 2007 Jul;107(1):128-35.


Interleukin (IL)-1 in the cerebrospinal fluid (CSF) was examined using Western blotting, and brains were immunohistochemically examined for caspase-1 and IL-1beta.
3(0,0,0,3) Details
18827361 Okemoto K, Hanada K, Nishijima M, Kawasaki K: The preparation of a lipidic endotoxin affects its biological activities. Biol Pharm Bull. 2008 Oct;31(10):1952-4.


Macrophages stimulated with OL or lipid A sonically dissolved in saline released both interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha).
2(0,0,0,2) Details
19661176 Cervantes-Sandoval I, Serrano-Luna Jde J, Meza-Cervantez P, Arroyo R, Tsutsumi V, Shibayama M: Naegleria fowleri induces MUC5AC and pro-inflammatory cytokines in human epithelial cells via ROS production and EGFR activation. Microbiology. 2009 Nov;155(Pt 11):3739-47. Epub 2009 Aug 6.


Furthermore, the expression of MUC5AC, IL-8 and IL-1 beta was inhibited in the presence of the ROS scavenger DMSO.
2(0,0,0,2) Details
19295477 Li Y, Liu B, Zhao H, Sailhamer EA, Fukudome EY, Zhang X, Kheirbek T, Finkelstein RA, Velmahos GC, deMoya M, Hales CA, Alam HB: Protective effect of suberoylanilide hydroxamic acid against LPS-induced septic shock in rodents. Shock. 2009 Nov;32(5):517-23.


Moreover, LPS insult decreased the acetylation of histone proteins (H2A, H2B, and H3), elevated the levels of TNF-alpha in vivo (circulation) and in vitro (culture medium), increased the neutrophilic cell population in the spleen, enhanced the expression of TNF-alpha and IL-1beta genes in lung tissue, and augmented the pulmonary neutrophil infiltration.
1(0,0,0,1) Details
17388412 Sando GM, Dahl K, Owrutsky JC: Vibrational spectroscopy and dynamics of azide ion in ionic liquid and dimethyl sulfoxide water mixtures. J Phys Chem B. 2007 May 10;111(18):4901-9. Epub 2007 Feb 28.


Steady-state and time-resolved infrared spectroscopy of the azide (N (3)-) anion has been used to characterize aqueous mixtures both with the ionic liquid (IL) 1-butyl-3-methylimidazolium tetrafluoroborate ([BMIM][BF (4)]) and with dimethyl sulfoxide (DMSO).
1(0,0,0,1) Details
19757177 Chan JY, Li L, Miao J, Cai DQ, Lee KK, Chui YL: Differential expression of a novel gene BRE (TNFRSF1A modulator/BRCC45) in response to stress and biological signals. Mol Biol Rep. 2010 Jan;37(1):363-8.


BRE protein expression was unaltered in cells treated with TNF-alpha, Interleukin-1 and Dexamethasone, while a threefold increase was observed following chorionic gonadotropin exposure.
1(0,0,0,1) Details
17380792 Dugo L, Collin M, Allen DA, Patel NS, Bauer I, Mervaala E, Louhelainen M, Foster SJ, Yaqoob MM, Thiemermann C: Inhibiting glycogen synthase kinase 3beta in sepsis. . Novartis Found Symp. 2007;280:128-42; discussion 142-6


GSK-3beta inhibition reduced the increase in NF-kappaB p65 activity caused by interleukin (IL) 1 in human e mbryonic kidney cells in vitro.
1(0,0,0,1) Details
18457866 Saito M, Watanabe S: Differential modulation of lipopolysaccharide- and zymosan-induced hypophagia by dexamethasone treatment. Pharmacol Biochem Behav. 2008 Sep;90(3):428-33. Epub 2008 Apr 4.


The attenuated response was associated with the suppression of the gene induction of proinflammatory cytokines (i.e., IL-1beta, IL-6 and TNFalpha) in the brain and liver.
1(0,0,0,1) Details
17949278 Xing L, Remick DG: Promoter elements responsible for antioxidant regulation of MCP-1 gene expression. Antioxid Redox Signal. 2007 Nov;9(11):1979-89.


MCP-1 secretion and mRNA expression and transcription activity stimulated by TNF-alpha or IL-1beta were significantly inhibited by 1% DMSO in alveolar type II epithelial cells (A549).
1(0,0,0,1) Details