| 14568351 |
Pena-Llopis S, Ferrando MD, Pena JB: Fish tolerance to organophosphate-induced oxidative stress is dependent on the glutathione metabolism and enhanced by N-acetylcysteine. Aquat Toxicol. 2003 Dec 10;65(4):337-60.
Fish pre-treated with NAC (1 mmol kg (-1), i.p.) and exposed to 1.5 mg l (-1) (the 96-h LC85) of dichlorvos for 96 h in a static-renewal system achieved an increase of the GSH content, GSH/GSSG ratio, hepatic glutathione reductase (GR), glutathione S-transferase (GST), glutamate:cysteine ligase (GCL), and gamma-glutamyl transferase (gammaGT) activities, which ameliorated the glutathione loss and oxidation, and enzyme inactivation, caused by the OP pesticide. |
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