| 107617 |
Riviere JL, De Lavaur E, Grolleau G: Effect of polychlorinated biphenyls on drug metabolism in Japanese quail and its progeny. Toxicology. 1978 Dec;11(4):329-34.
PCB (DP5, 1 and 5 mg/female/day, orally for 40 days) induce microsomal hepatic enzymes (cytochrome P-450, aniline hydroxylase, aldrin epoxidase, p-nitroanisole demethylase, p-nitrophenol: UDPGA-transferase) in adult female Japanese quail. Toxicity of dinitro-o-cresol (DNOC) is reduced in treated animals. High hepatic activity occurs in young quails issued from treated females, but closely related to residue levels, normal enzyme activities are reestablished within 1 month. |
1(0,0,0,1) |