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Ijaz T, Tran P, Ruparelia KC, Teesdale-Spittle PH, Orr S, Patterson LH: Anthraquinone-peptides as inhibitors of AP-1 transcription factor. Bioorg Med Chem Lett. 2001 Feb 12;11(3):351-3.
Peptide-1-[N-[2-succinamidylethyl] amino] anthraquinones containing five seven amino acid residues including the KCR motif important in AP-1 protein binding to DNA have been synthesised as potential transcription factor inhibitors. These anthraquinone-peptides showed DNA intercalative binding and inhibition of AP-1 protein binding to its DNA consensus sequence. |
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