| 2826236 |
Sushkov DG, Gritsan NP, Weiner LM: Generation of OH radical during enzymatic reduction of 9,10-anthraquinone-2-sulphonate. FEBS Lett. 1987 Dec 10;225(1-2):139-44.
Can semiquinone decompose hydrogen peroxide?. Spin-trapping experiments have shown that 9,10-anthraquinone-2-sulphonate (AQS) can be reduced enzymatically with NADPH-cytochrome P-450 reductase (FP) producing OH radicals. It has been revealed for the first time that the radical anion of AQS cannot decompose H2O2 as indicated by flash-photolysis data. From the experimental results obtained it follows that an enzyme system containing NADPH, AQS and FP produces both accumulation of H2O2 from molecular oxygen and reduction of Fe3+ to Fe2+ which decomposes H2O2 catalytically via a Fenton reaction. |
81(1,1,1,1) |