| 2546562 |
Tarasiuk J, Garnier-Suillerot A, Borowski E: Lack of competition between cytochrome c and anthraquinone type drugs for the reductive sites of NADH dehydrogenase. Biochem Pharmacol. 1989 Jul 15;38(14):2285-9.
We have shown that (i) the cytochrome c reductase activity of the commercial NADH dehydrogenase does not perturb its ability to catalyse the reduction of various antitumor compounds of the anthracycline class, (ii) the reduction of these compounds by NADH, catalysed by commercial NADH dehydrogenase, correlates with their reduction by NADH catalysed by microsomes. Moreover, our data strongly suggest that two catalytic sites are present, one for cytochrome c and one for quinone type compounds. |
6(0,0,1,1) |