Protein Information

ID 1089
Name cyclic nucleotide phosphodiesterase
Synonyms CNP; CNP 2; CNP2; Cyclic nucleotide phosphodiesterase; CNP 1; CNP1; CNPase; CNPases

Compound Information

ID 366
Name anthraquinone
CAS 9,10-anthracenedione

Reference

PubMed Abstract RScore(About this table)
3680022 Matsuda Y, Kase H: KS-619-1, a new inhibitor of Ca2+ and calmodulin-dependent cyclic nucleotide phosphodiesterase from Streptomyces californicus. J Antibiot. 1987 Aug;40(8):1104-10.
KS-619-1, a new inhibitor of Ca2+ and calmodulin-dependent cyclic nucleotide phosphodiesterase, was isolated from the cultured broth of Streptomyces californicus. KS-619-1 has an anthraquinone moiety. IC50 values for the effect of KS-619-1 on Ca2+ and calmodulin-stimulated activity of bovine brain and heart enzymes were 2.0 and 1.5 microM, respectively. On the other hand, basal activity (the activity in the presence of ethylene bis (oxyethylenenitrilo) tetraacetic acid (EGTA) instead of Ca2+/calmodulin) of the bovine brain enzyme, calmodulin-independent cyclic nucleotide phosphodiesterase from bovine heart, and protein kinase C from rat brain were inhibited by KS-619-1 to a lesser extent with IC50 values; 12.3, 25.9 and 151 microM, respectively.
3(0,0,0,3)