| 1693102 |
Jamison JM, Krabill K, Flowers DG, Tsai CC: Polyribonucleotide-anthraquinone interactions: in vitro antiviral activity studies. Cell Biol Int Rep. 1990 Mar;14(3):219-28.
Twelve anthraquinones (AQ) were evaluated for their ability to potentiate the antiviral activity of poly r (A-U) using a human foreskin fibroblast-vesicular stomatitis virus bioassay in which the AQ was combined with 0.2 mM poly r (A-U) to produce an AQ/ribonucleotide ratio of 1/4. Poly r (A-U) and the AQ alone were not effective antiviral agents. Five of the twelve AQs tested, mitoxantrone, adriamycin, ametantrone, carminic acid and daunomycin, enhanced the antiviral activity of poly r (A-U) 9- to 13-fold. The interferon-inducing activity of the five active AQ/poly r (A-U) combinations was equal to the sum of the interferon-inducing activities of their constituents. These five AQs appear to potentiate the antiviral activity of poly r (A-U) without superinduction of interferon. |
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