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Das S, Saha A, Mandal PC: Radiation-induced double-strand modification in calf thymus DNA in the presence of 1,2-dihydroxy-9,10-anthraquinone and its Cu (II) complex. Environ Health Perspect. 1997 Dec;105 Suppl 6:1459-62.
When cells or DNA is exposed to ionizing radiation, the radicals produced in the irradiated sample will modify the base-pair region of the double strands. Effects of 1,2-dihydroxy-9,10-anthraquinone (DHA) and its Cu (II) complex on the radiation-induced modification of double-strands in calf thymus DNA were studied using ethidium bromide as a fluorescent probe. Our results show that the Cu (II)-DHA complex is more efficient in modifying the base-pair region in double-stranded DNA compared to free DHA. |
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