| 2839361 |
Lachowiez RM, Hammoud NM, Teibel JL, Dix JA: Phospholipase activation, free fatty acids and the proton permeability of a biological membrane. FEBS Lett. 1988 Jul 4;234(1):195-8.
The rate of collapse of a proton gradient across the apical membrane of rat kidney proximal tubule increases upon treatment with calcium, mercuric chloride and mellitin, substances which activate phospholipase A2. Treatment with phospholipase A2 or oleic acid also enhances the rate of proton gradient dissipation. Membrane water permeability is not affected. This phenomenon may have implications in pathological states arising from ischemia or toxic exposure. |
82(1,1,1,2) |