| 890838 |
Arrhenius E, Renberg L, Johansson L: Subcellular distribution, a factor in risk evaluation of pentachlorophenol. Chem Biol Interact. 1977 Jul;18(1):23-34.
Pentachlorophenol (PCP) is a potent uncoupler of mitochondrial phosphorylation in vitro and also interferes with microsomal detoxication functions in vitro. This favours flavin mediated oxygenation compared with flavin cytochrome P-450 dependent reactions. Gas chromatographic analysis of subcellular fractions, obtained by zonal centrifugation showed markedly lower PCP concentration in mitochondria and a high accumulation in microsomes compared with cytosol. This increases the likelihood that PCP in vivo causes a malfunction in microsomal detoxication. |
1(0,0,0,1) |