10379902 |
Odunuga OO, Okunade GW, Olorunsogo OO: Reversal of sodium arsenite inhibition of rat liver microsomal Ca2+ pumping ATPase by vitamin C. Biosci Rep. 1999 Feb;19(1):11-5. Sodium arsenite (NaAsO2), at 10% of its median lethal dose, was administered to rats with and without vitamin C pretreatment. Liver microsomal fraction was isolated and the activity of Ca2+-ATPase was assayed. Sodium arsenite was found to inhibit the activity of the liver microsomal Ca2+-ATPase to 50% to that of control rats. The specific activity of the enzyme in rats administered sodium arsenite with vitamin C pretreatment was not significantly different from that of control rats. |
163(2,2,2,3) |