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Kagan IuS, Ovsiannikova LM, Luk'ianchuk VD: [Kinetics of the change in the level of metalloproteins and free radicals in the liver of rats with acute poisoning by alkyl derivatives of 2, 4-dinitrophenol]. Farmakol Toksikol. 1984 May-Jun;47(3):90-3.
Electron paramagnetic resonance was used to study over time metal proteins (cytochrome P-450, cytochrome-c-oxidase, iron and sulfur proteins) and free radicals in rat liver under acute (LD50) oral intoxication with 2,4-dinitro-6-butylphenol and 2,4-dinitro-6-methylphenol used as pesticides. The authors describe the kinetics of variations in the content of metal proteins and free radicals under the effect of the above-indicated toxic agents. It is assumed that the triggering mechanism of the toxic action of dinitrophenols lies in the inhibition of the function of iron and sulfur proteins. Possible mechanisms of the disturbance of the energy and detoxifying systems of the body under experimental conditions described are reviewed. |
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