| 18359707 |
Liu J, Liu YH: [Expression of CD117, CD34, SMA, S-100 protein, Vim and desmin in patients with gastrointestinal stromal tumors]. Nan Fang Yi Ke Da Xue Xue Bao. 2008 Mar;28(3):438-40.
OBJECTIVE: To investigate the clinicopathological diagnosis and expressions of CD117, CD34, SMA, S-100 protein, Vimentin (Vim) and desmin in gastrointestinal stromal tumors (GISTs). METHODS: A retrospective analysis of the clinical data and the results of various examinations was conducted among 35 patients with pathologically confirmed GISTs undergoing surgical resection. The expressions of CD117, CD34, SMA, S-100, Vim and desmin in the tumor tissues were detected by immunohistochemistry with SP method. RESULTS: In these GIST cases, the tumors were located mostly in the stomach (n=11), small intestines (n=11), and abdominal cavity (n=5). The main clinical manifestations included abdominal distension, abdominal pain, gastrointestinal bleeding, and abdominal masses. The positivity rates of CD117 and CD34 in the tumors were 94.3% and 91.4%, respectively, both significantly higher than those of SMA, S-100, Vim and Desmin (P <0.001), and also higher than that in leiomyoma (P <0.0001). The positivity rate of Desmin was only 2.9% in the tumors, significantly lower than those of CD117 and CD34 (P <0.05) and that in liomyoma (P <0.001). CONCLUSIONS: GISTs occur mostly in the stomach and small intestines, and endoscopy, ultrasound endoscope and CT examination are effective modalities for diagnosis of GISTs. A definite diagnosis of GISTs can be established in the presence of positive expression of CD117 and CD34 and negative expression of Desmin in the tumor. |
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