| 734985 |
Ivanov VV, Kuznetsova GP, Archakov AI: [Acrylonitrile stimulation of lipid peroxidation in rat liver] . Vopr Med Khim. 1978 Nov-Dec;24(6):816-8.
Acrylonitrile stimulated slightly the lipid peroxidation in isolated microsomes and exhibited distinct prooxidative effect in postmitochondrial supernatant, containing microsomes and cell juice. Acrylonitrile did not form a complex with cytochrome P-450, possessing distinct spectral properties of the I or II types, and did not stimulate the oxygen utilization by microsomes in presence of NADPH. The hepatotoxic effect of acrylonitrile appears to be due to its property to stimulate the formation of lipid peroxides in hepatocytes. |
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