| 11938971 |
Zhang Z, Wang X, Zhou J, Gao S, Jin X: [Effect of acrylonitrile on the activity of Ca (2+)-ATPase and phosphorylase A of liver in rats]. Wei Sheng Yan Jiu. 1999 Jul;28(4):194-5.
The activity of Ca (2+)-ATPase and phosphorylase A (P-A) of liver in rats was determined to study the effect of acrylonitrile (ACN) on calcium homeostasis and to clarify the toxicological mechanism of ACN. Adult male Sprague-Dawley rats were administered ACN daily per os for 42 days, at the dosage of 0, 10, 30 and 50 mg.kg-1. The activities of Ca (2+)-ATPase and phosphorylase A was determined at 14, 28, 42 days after ACN administration. The results indicated that ACN could significantly inhibit the activity of Ca (2+)-ATPase and increase the activity of P-A (P < 0.01), especially in the high dose group and exposed for 42 days, and there was significantly dose- and time-respond relationship (P < 0.01). ACN contamination could result in the disharmony of calcium homeostasis of liver in rats. |
14(0,0,2,4) |