| 18484769 |
Lin KW, Chen CY, Chen WF, Yan TH: A new entry to 1,5-keto esters and their 4,4-dideuterio derivatives via methylene chloride as "methylene dianion" equivalents. J Org Chem. 2008 Jun 20;73(12):4759-61. Epub 2008 May 17.
This TiCl 4-Mg promoted multicomponent coupling of various amides with CH (2) Cl (2) and methyl acrylate represents an extremely simple and practical synthesis of 1,5-keto esters. The efficiency of this chemistry is illustrated by the very simple preparation of unusual 4,4-dideuterio-1,5-keto esters. |
1(0,0,0,1) |