| 19560047 |
Penton RE, Lester RA: Cellular events in nicotine addiction. Lung. 2010 Jan;188 Suppl 1:S23-7. Epub 2009 Oct 21.
In the 25 years since the observation that chronic exposure to nicotine could regulate the number and function of high affinity nicotine binding sites in the brain there has been a major effort to link alterations in nicotinic acetylcholine receptors (nAChRs) to nicotine-induced behaviors that drive the addiction to tobacco products. Here we review the proposed roles of various nAChR subtypes in the addiction process, with emphasis on how they are regulated by nicotine and the implications for understanding the cellular neurobiology of addiction to this drug. |
81(1,1,1,1) |