| 7376196 |
Carlson GP: Induction of xenobiotic metabolism in rats by short-term administration of brominated diphenyl ethers. Toxicol Lett. 1980 Jan;5(1):19-25.
Commercial preparations of fire retardant brominated diphenyl ethers were tested along with bis (p-bromophenyl) ether and diphenyl ether for their ability to alter xenobiotic metabolism. The materials, 0.1 mmol/kg/day, were administered p.o. to male rats for 14 days. Pentabromodiphenyl and octabromodiphenyl ether preparations increased O-ethyl O-p-nitrophenyl phenylphosphonothioate (EPN) detoxification, p-nitroanisole demethylation, NADPH-cytochrome c reductase, cytochrome P-450, liver weight, UDP-glucuronyltransferase and benzo [a] pyrene hydroxylase. Diphenyl ether increased only EPN detoxification and decabromodiphenyl ether only liver weight. Bis (p-bromophenyl) ether increased liver weight, cytochrome c reductase and cytochrome P-450. The data indicate that these materials are inducers of xenobiotic metabolism with activity dependent upon degree of bromination. |
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