| ID | 47 |
|---|---|
| Name | cytochrome P450 (protein family or complex) |
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| ID | 1468 |
|---|---|
| Name | HCH |
| CAS | 1,2,3,4,5,6-hexachlorocyclohexane |
| PubMed | Abstract | RScore(About this table) |
|---|---|---|
| 77193 | Seifert J, Vacha J, Seifertova M: Liver growth, biosynthesis of nucleotides and level of cytochrome P-450 in rat liver after administration of alpha-hexachlorocyclohexane. Chem Biol Interact. 1978 Feb;20(2):227-38. The biosynthesis of nucleotides and the level of microsomal cytochrome P-450 in intact and regenerating rat liver after repeated administration of alpha-hexachlorocyclohexane (alpha-HCH) were compared. In alpha-HCH treated animals the utilization of [2-14C] for the synthesis of nucleotides is suppressed. In 24-h regenerating liver the incorporation of labelled into nucleotides is markedly activated; the degree of activation is lower in regenerating livers of alpha-HCH treated animals. The changes in the level of cytochrome P-450 vary inversely with the changes in the utilization of [2-14C] for the synthesis of nucleotides. The activity of synthetase of liver cytosol increases shortly after the administration of alpha-HCH; - kinase is enhanced in the later stages of the drug action. Within 15-45 min after the administration of alpha-HCH the uptake of [U-14 C] into the liver and its incorporation into RNA are increased. After the administration of the drug the uptake of [2-14 C] and its incorporation into RNA is also enhanced whereas its utilization for the synthesis of nucleotides of the acid-soluble extract as well as for the RNA are suppressed. |
3(0,0,0,3) |