| 288361 |
Malvoisin E, Roberfroid M, Mercier M: Microsomal vinyl oxide synthetase: modification of its kinetic parameters by chemical carcinogens. Arch Toxicol Suppl. 1979;(2):465-9.
The kinetic parameters of liver microsomal vinyl oxide synthetase as well as their modifications under the influence of various pretreatments have been evaluated, using 1,1,2-trichlorethylene (TCE) as a substrate. The results were correlated with those obtained using aldrin oxide synthetase and benzpyrene hydroxylase as typical cytochrome P-450 dependent enzymatic activity. The treatments of animals with chemical carcinogens selectively increase the affinity of those enzymes for their substrates. |
6(0,0,1,1) |