| 2719725 |
Peters WH, Kremers PG: Cytochromes P-450 in the intestinal mucosa of man. Biochem Pharmacol. 1989 May 1;38(9):1535-8.
With monoclonal antibodies against cytochrome P-450 (5) and P-450 (4,5,6), 52 and 54 kDa bands are visualized in microsomes from proximal as well as distal human small intestine. These bands most probably correspond to cytochrome P-450 (5) and P-450 (4), respectively. This and several other cytochrome P-450 related proteins are present in hepatic microsomes from the same patient. In both hepatic and intestinal microsomes from this patient cytochrome P-450 (8) is hardly detectable. In contrast to the small intestine and liver, large intestinal tissue from several other patients does not contain cytochrome P-450 (5). Here the 54 kDa isoenzyme, possibly cytochrome P-450 (4), is most prominent. Earlier we found a higher content of total cytochrome P-450 in the proximal as compared to the distal small intestine. A similar distribution is now found with regard to aldrin epoxidase activity. |
6(0,0,0,6) |