| 6803311 |
Bansal SK, Li HC, Holmes G, Gessner T: On the functional heterogeneity of UDP-glucuronyl transferase of mouse liver microsomes. Res Commun Chem Pathol Pharmacol. 1982 Feb;35(2):291-302.
Fractionation of sodium cholate solubilized microsomes from mouse liver on Sepharose CL-48 yielded three protein peaks with UDP-glucuronyltransferase activities. Of these three peaks, only peak II contained activities towards all the substrates tested: p-nitrophenol, 1-naphthol, morphine, testosterone and estrone. These glucuronyltransferase activities could not be dissociated by further chromatography on DEAE-Sepharose CL-6B and isoelectric focusing. The results show the presence of a functional form of glucuronyltransferase with a wide substrate specificity, and indicate that in addition, other forms with narrower studied specificities may also be present in mouse liver microsomes. |
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