| 16257471 |
Hayrapetyan V, Jenschke M, Dillon GH, Machu TK: Co-expression of the 5-HT (3B) subunit with the 5-HT (3A) receptor reduces alcohol sensitivity. Brain Res Mol Brain Res. 2005 Dec 14;142(2):146-50. Epub 2005 Oct 28.
Allosteric modulation of mouse 5-Hydroxytryptamine (3A) (5-HT (3A)) and 5-HT (3A/B) receptor function by ethanol and trichloroethanol (TCEt) was assessed in HEK293 cells with whole cell patch-clamp electrophysiological recordings. Ethanol enhanced 5-HT (3A) receptor function, but had no effect on mouse 5-HT (3A/B) receptor mediated currents. The enhancing action of trichloroethanol (TCEt) on mouse 5-HT (3A/B) receptor function was much less than that observed in the mouse 5-HT (3A) receptor. Where alcohol-induced increases in peak amplitude were observed, the slope of the 20-80% rising phase of current onset was also enhanced, suggesting that increases in activation rate may be one mechanism through which alcohols enhance function of the 5-HT (3) receptors. |
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