| 17191925 |
Vazquez MJ, Albarran MI, Espada A, Rivera-Sagredo A, Diez E, Hueso-Rodriguez JA: A new destruxin as inhibitor of vacuolar-type H+-ATPase of Saccharomyces cerevisiae. Chem Biodivers. 2005 Jan;2(1):123-30.
In the course of our screening efforts to discover small molecules as selective inhibitors of vacuolar-type H+-ATPase of Saccharomyces cerevisiae, we have identified eight active destruxins, 1-8, from the fungus Metarhizium anisopliae. The structures were elucidated by extensive 1D- and 2D-NMR spectroscopy, and MS spectrometry. One of these compounds, 8, a regioisomer of chlorohydrin destruxin E (7), is a new destruxin. |
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