| 2904384 |
de Miguel C, Encio I, Lopez-Moratalla N, Santiago E: Interaction of F1-ATPase and its inhibitor peptide. Int J Biochem. 1988;20(9):983-7.
Effect of dinitrophenol, nucleotides and anions.. 1. ATPase natural inhibitor interacted in a mixed non-competitive manner with compounds affecting hydrolytic activity. 2. Ka's for DNP, HCO3- and free ATP, and Ki's for SCN- and ADP became smaller as inhibitor peptide concentration increased, reflecting an increase in affinity of F1-ATPase for these compounds induced by the peptide. 3. Activators increased the peptide inhibitory effect, whereas inhibitors decreased it. 4. A two-step model for the peptide-enzyme interaction is suggested in which ATP hydrolysis is a key factor. |
3(0,0,0,3) |