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Hinson JA, Mitchell JR: N-Hydroxylation of phenacetin by hamster liver microsomes. . Drug Metab Dispos. 1976 Sep-Oct;4(5):430-5.
Hamster liver microsomes have been shown to catalyze the N-hydroxylation of phenacetin. The reaction, which requires oxygen and NADPH, is inhibited by a carbon monoxide/oxygen atmosphere, indicating that it is catalyzed by a cytochrome P-450-dependent mixed-function oxidase. The N-hydroxyphenacetin can be further metabolized by the microsomes, and the reaction is inhibited by phenacetin. |
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