| 6623496 |
Reinders JH, Hansen LG, Metcalf RL: In vitro neurotoxic esterase assay using leptophos oxon analogs as inhibitors. Toxicol Lett. 1983 Jun;17(1-2):107-11.
In comparing neurotoxic esterase (NTE) inhibition properties of a series of phenylphosphonates, it was discovered that certain compounds including leptophos inhibited mipafox-insensitive phenylvalerate hydrolases. This leads to erroneous values for NTE inhibition which can be corrected by a differential assay: the total amount of mipafox-insensitive activity is determined with O-(2,6-dichlorophenyl) O-methyl phenylphosphonate and subtracted from the apparent NTE determined with the test compound before calculating pI50's. |
32(0,1,1,2) |