| 17392689 |
Chambers JE, Boone JS, Davis MK, Moran JE, Tyler JW: Assessing transferable residues from intermittent exposure to flea control collars containing the organophosphate insecticide chlorpyrifos. J Expo Sci Environ Epidemiol. 2007 Nov;17(7):656-66. Epub 2007 Mar 28.
Children can be exposed to pesticides from numerous residential sources such as carpet, house dust, toys and clothing from treated homes, and flea control remedies on pets. In the present studies, 48 pet dogs (24 in each of two studies) of different breeds and weights were treated with over-the-counter flea collars containing chlorpyrifos (CP), an organophosphorus insecticide. Transferable insecticide residues were quantified on cotton gloves used to rub the dogs for 5 min and on cotton tee shirts worn by a child (Study 2 only). First morning urine samples were also obtained from adults and children in both studies for metabolite (3,5,6-trichloro-2-pyridinol) quantification. Blood samples were obtained from treated dogs in Study 1 and plasma cholinesterase (ChE) activity was monitored. Transferable residues on gloves for all compounds were highest near the neck of the dogs and were lowest in areas most distant from the neck. Rubbing samples (over the collar) at two weeks post-collar application contained 447+/-57 microg CP/glove while samples from the fur of the back contained 8+/-2 microg CP/glove. In Study 2, cotton tee shirts worn by children at 15 days post-collar application for 4 h showed CP levels of 134+/-66 ng/g shirt. There were significant differences between adults and children in the levels of urinary metabolites with children generally having higher urinary levels of metabolites than adults (grand mean+/-SE; 11.6+/-1.1 and 7.9+/-0.74 ng/mg creatinine for children and adults, respectively, compared to 9.4+/-0.8 and 6.9+/-0.5 ng/mg creatinine before collar placement). Therefore, there was little evidence that the use of this flea collar contributed to enhanced CP exposure of either children or adults. |
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