Protein Information

ID 88
Name Acetylcholinesterase
Synonyms ACHE; ACHE protein; AChE; ARACHE; AcChoEase; Acetylcholine acetylhydrolase; Acetylcholinesterase; Acetylcholinesterase isoform E4 E6 variant…

Compound Information

ID 202
Name chlorpyrifos
CAS

Reference

PubMed Abstract RScore(About this table)
12020023 Byrne FJ, Toscano NC: Evaluation of peracid activated organophosphates in studies of insecticide resistance conferred by insensitive acetylcholinesterases. J Econ Entomol. 2002 Apr;95(2):425-9.
Peracid activated organophosphorus (OP) insecticides were evaluated against electric eel and a range of insect acetylcholinesterases (AChE). Incubation of chlorpyrifos and sulprofos with meta-chloroperoxybenzoic acid (MCPBA) produced active metabolites capable of distinguishing between AChE enzymes conferring OP susceptibility and resistance in populations of the tobacco whitefly, Bemisia tabaci Gennadius, and the beet armyworm, Spodoptera exigua Hubner. These products were also active against enzymes present in the lygus bug Lygus hesperus Knight and the greenhouse whitefly, Trialeurodes vaporariorum Westwood. Although profenofos was active against electric eel AChE, incubation of the OP with MCPBA did not enhance its anti-AChE properties toward the eel or insect AChEs.
83(1,1,1,3)