| 11205075 |
Guadarrama-Naveda M, de Cabrera LC, Matos-Bastidas S: Intermediate syndrome secondary to ingestion of chlorpiriphos. Vet Hum Toxicol. 2001 Feb;43(1):34.
A rural-area resident male patient deliberately ingested chlorpiriphos, an organophosphate insecticide. Although presented with cholinergic symptoms initially, he suffered general condition deterioration after 4 d characterized by muscular weakness, hypotonia, arreflexia and recumbent dyspnea requiring ventilatory support. These clinical manifestations occur from liposoluble organophosphates or metabolites with long-lasting half time, causeing delayed inhibition of acetylcholinesterase and subsequent burn out of the neuromuscular junction from acetylcholine overstimulation. |
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