| 10455279 |
Matsuda K, Hosie AM, Holyoke CW Jr, Rauh JJ, Sattelle DB: Cross-resistance with dieldrin of a novel tricyclic dinitrile GABA receptor antagonist. Br J Pharmacol. 1999 Jul;127(6):1305-7.
A novel tricyclic dinitrile, KN244, blocked the wild-type (dieldrin-sensitive) homo-oligomeric gamma-aminobutyric acid (GABA)-gated chloride channel of Drosophila melanogaster expressed in Xenopus oocytes. Sensitivity to the block by KN244 of the response to 30 microM GABA (IC50=41.6 nM, wild-type RDLac) was reduced abut 100 fold (IC50=4.5 microM) in the dieldrin-resistant (RDLacA302S) form of RDL. |
31(0,1,1,1) |