| 8842342 |
Naz S, Khan KA, Zubairi SA: In vitro studies of the loss of antibacterial activity of oxytetracycline in presence of Ca (II) or Mg (II) ions. Arzneimittelforschung. 1996 Jul;46(7):701-4.
The results of a comparative study, which evaluated the in vitro effect on the antibacterial activity of oxytetracycline (OTC, CAS 79-57-2) in presence of Ca (II)/Mg (II) ions suggest that susceptibility of Staphylococcus aureus, Bacillus pumilis and Bacillus subtilis to OTC is reduced in presence of Ca (II)/Mg (II) ions. As the ratio of concentration of Ca (II)/Mg (II) to OTC was increased, antibacterial activity of OTC declined. In addition to the difference observed between the antibacterial effect of pure OTC and its Ca (II)/Mg (II) complexes, it was found that decline in antibacterial activity is greater for Mg (II)-OTC complex than Ca (II)-OTC complex for the same concentration of Ca (II)/Mg (II) ions. |
89(1,1,2,4) |