Protein Information

ID 471
Name IL 8
Synonyms 3 10C; AMCF I; CXC chemokine ligand 8; CXCL 8; CXCL8; Emoctakin; GCP 1; GCP1…

Compound Information

ID 309
Name sulfur
CAS sulfur

Reference

PubMed Abstract RScore(About this table)
19932683 Chen W, Kajiya M, Giro G, Ouhara K, Mackler HE, Mawardi H, Boisvert H, Duncan MJ, Sato K, Kawai T: Bacteria-derived hydrogen sulfide promotes IL-8 production from epithelial cells. Biochem Biophys Res Commun. 2010 Jan 1;391(1):645-50. Epub 2009 Nov 22.
Hydrogen sulfide (H (2) S), a volatile sulfur compound, is implicated as a cause of inflammation, especially when it is produced by bacteria colonizing gastrointestinal organs. However, it is unclear if H (2) S produced by periodontal pathogens affects the inflammatory responses mediated by oral/gingival epithelial cells. Therefore, the aims of this study were (1) to compare the in vitro production of H (2) S among 14 strains of oral bacteria and (2) to evaluate the effects of H (2) S on inflammatory response induced in host oral/gingival epithelial cells. Porphyromonas gingivalis (Pg) produced the most H (2) S in culture, which, in turn, resulted in the promotion of proinflammatory cytokine IL-8 from both gingival and oral epithelial cells. The up-regulation of IL-8 expression was reproduced by the exogenously applied H (2) S. Furthermore, the mutant strains of Pg that do not produce major soluble virulent factors, i.e. gingipains, still showed the production of H (2) S, as well as the promotion of epithelial IL-8 production, which was abrogated by H (2) S scavenging reagents. These results demonstrated that Pg produces a concentration of H (2) S capable of up-regulating IL-8 expression induced in gingival and oral epithelial cells, revealing a possible mechanism that may promote the inflammation in periodontal disease.
4(0,0,0,4)