| 19759948 |
Kunz PC, Kassack MU, Hamacher A, Spingler B: Imidazole-based phosphane gold (I) complexes as potential agents for cancer treatment: synthesis, structural studies and antitumour activity. Dalton Trans. 2009 Oct 7;(37):7741-7. Epub 2009 Jul 30.
The reaction of the imidazolyl-4 (5)-phosphane ligands 2-isopropylimidazol-4 (5) yl-diphenylphosphane (4-MIP (iPr)) and tris (2-isopropylimidazol-4 (5) yl) phosphane (4-TIP (iPr)) towards gold (I) has been explored and compared to those of analogous 1-methylimidazol-2-ylphosphane ligands. The structure of [(4-MIP (iPr)) AuCl] () shows a linear P-Au-Cl coordination, whereas the 4-TIP (iPr) ligand forms a dinuclear complex [{(4-TIP (iPr)) Au}(2)] Cl (2) (). Here, 4-TIP (iPr) bridges two gold (I) atoms in a head-to-tail P,N fashion. Complex forms in the presence of the hard Lewis acid ZnCl (2) the bimetallic complex [AuCl (4-TIP (iPr)) ZnCl] Cl (), in which 4-TIP (iPr) bridges the two metal centers. In accordance with the HSAB concept the Au (I) atom is coordinated by the P atom and the zinc (II) by three N atoms in a N,N,N fashion. The solid-state structures of the complexes have been elucidated by single-crystal X-ray analysis. The Au (I)-Au (I) contact in is 2.8821 (15) A. The biological activities of all imidazol-2-yl- and imidazol-4 (5)-ylphosphane gold (I) complexes towards nine human cancer cell lines including seven ovarian cancer cell lines of different sensitivity towards cisplatin and two leukemia cell lines have been explored. |
1(0,0,0,1) |