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Chen ZG, Wang Y, Wei JF, Zhao PF, Shi XY: K3PO4-catalyzed regiospecific aminobromination of beta-nitrostyrene derivatives with N-bromoacetamide as aminobrominating agent. J Org Chem. 2010 Mar 19;75(6):2085-8.
A very simple, efficient, and regiospecific protocol for aminobromination of a wide scope of beta-nitrostyrene derivatives with N-bromoacetamide (NBA) as nitrogen/bromine sources has been developed by using K (3) PO (4) as catalyst. The reaction proceeded smoothly and cleanly to give the bromoamines in good to excellent yields (78-99%) within 24 h in CH (2) Cl (2) at room temperature without protection of inert gases. A possible mechanism involving a nucleophilic conjugate addition was proposed. |
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