| ID | 47 |
|---|---|
| Name | cytochrome P450 (protein family or complex) |
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| ID | 483 |
|---|---|
| Name | hexachlorobenzene |
| CAS | 1,2,3,4,5,6-hexachlorobenzene |
| PubMed | Abstract | RScore(About this table) |
|---|---|---|
| 7395266 | Vizethum W, Burkhardt F, Goerz G: Enzymic and electrophoretic characterization of the hexachlorobenzene-induced cytochrome P-450 in the liver of rat. Xenobiotica. 1980 Feb;10(2):145-50. 1. Hexachlorobenzene induces the cytochtome P-450 system in rat liver microsomes. The catalytic activity of the enzyme towards various substrates (dealkylation of 7-ethoxycoumarin, hydroxylation of biphenyl and -dependent reduction of cytochrome c) corresponds to that obtained in animals treated with a mixture of phenobarbital and benzpyrene. 2. Electrophoretic separation of the partly purified hexachlorobenzene-induced cytochrome P-450 in polyacrylamide gels exhibits a protein pattern similar to that found in microsomes from rats treated with phenobarbital plus benzpyrene. |
12(0,0,2,2) |